| http://purl.uniprot.org/citations/25832656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25832656 | http://www.w3.org/2000/01/rdf-schema#comment | "The growth factor PDGF controls the development of glioblastoma (GBM), but its contribution to the function of GBM stem-like cells (GSC) has been little studied. Here, we report that the transcription factor FoxM1 promotes PDGFA-STAT3 signaling to drive GSC self-renewal and tumorigenicity. In GBM, we found a positive correlation between expression of FoxM1 and PDGF-A. In GSC and mouse neural stem cells, FoxM1 bound to the PDGF-A promoter to upregulate PDGF-A expression, acting to maintain the stem-like qualities of GSC in part through this mechanism. Analysis of the human cancer genomic database The Cancer Genome Atlas revealed that GBM expresses higher levels of STAT3, a PDGF-A effector signaling molecule, as compared with normal brain. FoxM1 regulated STAT3 transcription through interactions with the β-catenin/TCF4 complex. FoxM1 deficiency inhibited PDGF-A and STAT3 expression in neural stem cells and GSC, abolishing their stem-like and tumorigenic properties. Further mechanistic investigations defined a FoxM1-PDGFA-STAT3 feed-forward pathway that was sufficient to confer stem-like properties to glioma cells. Collectively, our findings showed how FoxM1 activates expression of PDGF-A and STAT3 in a pathway required to maintain the self-renewal and tumorigenicity of glioma stem-like cells."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-14-2800"xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Huang S."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Yuan Y."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Rao G."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Wei P."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Lang F.F."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Heimberger A.B."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Zhou A.D."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/author | "Gong A.H."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/pages | "2337-2348"xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/title | "FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells."xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://purl.uniprot.org/core/volume | "75"xsd:string |
| http://purl.uniprot.org/citations/25832656 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25832656 |
| http://purl.uniprot.org/citations/25832656 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25832656 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SFF0-mappedCitation-25832656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832656 |
| http://purl.uniprot.org/uniprot/#_B7ZA24-mappedCitation-25832656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832656 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V395-mappedCitation-25832656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832656 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ0-mappedCitation-25832656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832656 |
| http://purl.uniprot.org/uniprot/#_A0A2P9DTZ1-mappedCitation-25832656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25832656 |