| http://purl.uniprot.org/citations/25847389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25847389 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysfunction of the hematopoietic microenvironment is the main obstacle encountered during hematopoiesis reconstruction in patients with acute hematopoietic radiation syndrome. Bone marrow mesenchymal stem cells (BM-MSCs) play a crucial supporting role in hematopoiesis by maintaining the balance between adipogenic and osteogenic differentiation. In this study, we found that irradiation decreased the colony-forming efficiency of BM-MSCs and impaired the balance between adipogenic and osteogenic differentiation. Following irradiation, BM-MCSs became strongly predisposed to adipogenesis, as evidenced by increased oil red O staining and elevated mRNA and protein levels of the adipogenic markers and transcription factors PPARγ and AP2. Overexpression of the essential adipogenesis regulator Crif1 in BM-MSCs promoted adipogenesis after irradiation exposure by upregulating adipogenesis-related genes, including C/EBPβ, PPARγ, and AP2. We found that Crif1 promoted the phosphorylation of cAMP response element binding protein (CREB) through direct interaction with protein kinase A (PKA)-α. Phosphorylation of CREB was inhibited in Crif1-knockdown BM-MSCs even in the presence of a PKA agonist (db-cAMP) and could be suppressed in Crif1-overexpressing BM-MSCs by a PKAα inhibitor (H-89). These results suggest that Crif1 is an indispensable regulator of PKAα cat that modulates the PKA/CREB signaling pathway to promote adipogenic differentiation of BM-MSCs after irradiation."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.org/dc/terms/identifier | "doi:10.1002/stem.2019"xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Xiao Y."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Xiang L."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Ran Q."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/author | "Zhong J.F."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/pages | "1915-1926"xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/title | "Crif1 Promotes Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells After Irradiation by Modulating the PKA/CREB Signaling Pathway."xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/25847389 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25847389 |
| http://purl.uniprot.org/citations/25847389 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25847389 |
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| http://purl.uniprot.org/uniprot/#_Q8TAE8-mappedCitation-25847389 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25847389 |
| http://purl.uniprot.org/uniprot/Q8TAE8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25847389 |
| http://purl.uniprot.org/uniprot/Q7LAX7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25847389 |