| http://purl.uniprot.org/citations/25858807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25858807 | http://www.w3.org/2000/01/rdf-schema#comment | "Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid release to sustain liver gluconeogenesis and tissue protein synthesis. These conditions activate the family of Forkhead Box (Fox) O transcription factors. Here we report that muscle-specific deletion of FoxO members protects from muscle loss as a result of the role of FoxOs in the induction of autophagy-lysosome and ubiquitin-proteasome systems. Notably, in the setting of low nutrient signalling, we demonstrate that FoxOs are required for Akt activity but not for mTOR signalling. FoxOs control several stress-response pathways such as the unfolded protein response, ROS detoxification, DNA repair and translation. Finally, we identify FoxO-dependent ubiquitin ligases including MUSA1 and a previously uncharacterised ligase termed SMART (Specific of Muscle Atrophy and Regulated by Transcription). Our findings underscore the central function of FoxOs in coordinating a variety of stress-response genes during catabolic conditions."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7670"xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Goldberg A.L."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "DePinho R.A."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Sandri M."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Abraham R."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Blaauw B."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Romanello V."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Seydel A."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Milan G."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Armani A."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Paik J.H."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Frasson L."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/author | "Pescatore F."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/pages | "6670"xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/title | "Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy."xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25858807 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25858807 |
| http://purl.uniprot.org/citations/25858807 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25858807 |
| http://purl.uniprot.org/uniprot/#_A0A087WRZ7-mappedCitation-25858807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25858807 |
| http://purl.uniprot.org/uniprot/#_E0CZ30-mappedCitation-25858807 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25858807 |