| http://purl.uniprot.org/citations/25862242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25862242 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila oskar (osk) mRNA is unusual in that it has both coding and noncoding functions. As an mRNA, osk encodes a protein required for embryonic patterning and germ cell formation. Independent of that function, the absence of osk mRNA disrupts formation of the karyosome and blocks progression through oogenesis. Here we show that loss of osk mRNA also affects the distribution of regulatory proteins, relaxing their association with large RNPs within the germline, and allowing them to accumulate in the somatic follicle cells. This and other noncoding functions of the osk mRNA are mediated by multiple sequence elements with distinct roles. One role, provided by numerous binding sites in two distinct regions of the osk 3' UTR, is to sequester the translational regulator Bruno (Bru), which itself controls translation of osk mRNA. This defines a novel regulatory circuit, with Bru restricting the activity of osk, and osk in turn restricting the activity of Bru. Other functional elements, which do not bind Bru and are positioned close to the 3' end of the RNA, act in the oocyte and are essential. Despite the different roles played by the different types of elements contributing to RNA function, mutation of any leads to accumulation of the germline regulatory factors in the follicle cells."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.048298.114"xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Macdonald P.M."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Ephrussi A."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Reich J."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Ryu Y.H."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Gstir R."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Jambor H."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Kanke M."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/author | "Marches B."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/pages | "1096-1109"xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/title | "oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction."xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/25862242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25862242 |
| http://purl.uniprot.org/citations/25862242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25862242 |
| http://purl.uniprot.org/uniprot/Q9VFP5#attribution-D7CBD25C5734FB0000CAD2AEA539ED13 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25862242 |
| http://purl.uniprot.org/uniprot/Q8IP90#attribution-811B95FCBBAEDEE12FB404FF8A6FFA2C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25862242 |
| http://purl.uniprot.org/uniprot/Q8IP90#attribution-D7CBD25C5734FB0000CAD2AEA539ED13 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25862242 |
| http://purl.uniprot.org/uniprot/Q9VCN7#attribution-D7CBD25C5734FB0000CAD2AEA539ED13 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25862242 |
| http://purl.uniprot.org/uniprot/#_A0A9F2H0X2-mappedCitation-25862242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25862242 |
| http://purl.uniprot.org/uniprot/#_O18409-mappedCitation-25862242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25862242 |
| http://purl.uniprot.org/uniprot/#_E2QC83-mappedCitation-25862242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25862242 |