| http://purl.uniprot.org/citations/25865883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25865883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25865883 | http://www.w3.org/2000/01/rdf-schema#comment | "MDA5 is a cytoplasmic viral double-stranded RNA (dsRNA) sensor and triggers type I interferon (IFN) production. MDA5 assembles along viral dsRNA, leading to the formation of an MDA5 filament required for activating the MAVS adaptor. A recent study has revealed that PP1α and PP1γ phosphatases are responsible for dephosphorylating MDA5 and are essential for its activation. Here, we identified RIO kinase 3 (RIOK3) as a protein kinase that phosphorylates the MDA5 C-terminal region. RIOK3 knockout strongly enhanced type I IFN and IFN-inducible gene expression following measles virus infection. Conversely, the ectopic expression of RIOK3 or a phosphomimetic MDA5-S828D mutation attenuated MDA5-mediated signaling. Moreover, RIOK3-mediated MDA5 phosphorylation impaired MDA5 multimer formation, indicating that MDA5 C-terminal phosphorylation interferes with MDA5 filament formation and suppresses its signaling. Our data revealed a regulatory mechanism underlying the activation of the cytoplasmic viral RNA sensor MDA5 in both uninfected and virus-infected cells."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.03.027"xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2015.03.027"xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Takashima K."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Takashima K."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Takaki H."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/author | "Takaki H."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/name | "Cell Rep."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/pages | "192-200"xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/pages | "192-200"xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/title | "RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/title | "RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response."xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/25865883 | http://purl.uniprot.org/core/volume | "11"xsd:string |