| http://purl.uniprot.org/citations/25870196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25870196 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we showed that Cyp1b1 gene disruption minimizes angiotensin II-induced hypertension and associated pathophysiological changes in male mice. This study was conducted to test the hypothesis that cytochrome P450 1B1-generated metabolites of testosterone, 6β-hydroxytestosterone and 16α-hydroxytestosterone, contribute to angiotensin II-induced hypertension and its pathogenesis. Angiotensin II infusion for 2 weeks increased cardiac cytochrome P450 1B1 activity and plasma levels of 6β-hydroxytestosterone, but not 16α-hydroxytestosterone, in Cyp1b1(+/+) mice without altering Cyp1b1 gene expression; these effects of angiotensin II were not observed in Cyp1b1(-/-) mice. Angiotensin II-induced increase in systolic blood pressure and associated cardiac hypertrophy, and fibrosis, measured by intracardiac accumulation of α-smooth muscle actin, collagen, and transforming growth factor-β, and increased nicotinamide adenine dinucleotide phosphate oxidase activity and production of reactive oxygen species; these changes were minimized in Cyp1b1(-/-) or castrated Cyp1b1(+/+) mice, and restored by treatment with 6β-hydroxytestoterone. In Cyp1b1(+/+) mice, 6β-hydroxytestosterone did not alter the angiotensin II-induced increase in systolic blood pressure; the basal systolic blood pressure was also not affected by this agent in either genotype. Angiotensin II or castration did not alter cardiac, angiotensin II type 1 receptor, angiotensin-converting enzyme, Mas receptor, or androgen receptor mRNA levels in Cyp1b1(+/+) or in Cyp1b1(-/-) mice. These data suggest that the testosterone metabolite, 6β-hydroxytestosterone, contributes to angiotensin II-induced hypertension and associated cardiac pathogenesis in male mice, most probably by acting as a permissive factor. Moreover, cytochrome P450 1B1 could serve as a novel target for developing agents for treating renin-angiotensin and testosterone-dependent hypertension and associated pathogenesis in males."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.115.05396"xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Lin Z."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Kara M."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Gonzalez F.J."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Estes A.M."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Malik K.U."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Khan N.S."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/author | "Pingili A.K."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/pages | "1279-1287"xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/title | "6beta-hydroxytestosterone, a cytochrome P450 1B1 metabolite of testosterone, contributes to angiotensin II-induced hypertension and its pathogenesis in male mice."xsd:string |
| http://purl.uniprot.org/citations/25870196 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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