| http://purl.uniprot.org/citations/25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25871737 | http://www.w3.org/2000/01/rdf-schema#comment | "Downregulation of major histocompatibility complex class I chain-related molecule A (MICA) and upregulation of human leukocyte antigen G (HLA-G) on the tumor cells are important immune escape mechanisms for different epithelial tumors. In addition, upregulation of the soluble forms of the latter molecules in serum leads to peripheral T-cell and natural killer (NK)-cell tolerance. As for cervical cancer, it remains unknown whether soluble MICA (sMICA) and soluble HLA-G (sHLA-G) concentrations are related to tumor characteristics or patient survival rates. We measured sMICA and sHLA-G in pre-treatment sera of a large cohort of cervical cancer patients (n = 366) by enzyme-linked immunosorbent assay (ELISA). We detected a median sMICA of 174.73 pg/ml and a median sHLA-G of 5.35 U/ml. We did not find an association between sHLA-G levels and clinicopathological characteristics. In adenocarcinoma, low sMICA concentration was positively related to recurrent disease, a higher International Federation of Gynecology and Obstetrics (FIGO) stage and vaginal involvement (Mann-Whitney U-test; P = 0.018, P = 0.042 and P = 0.013, respectively). In the latter patient group, high sMICA levels were associated with better disease-free survival (DFS) and disease-specific survival (DSS) (P = 0.011 and P = 0.047). After adjusting for confounding factors, high sMICA proved to be an independent predictor for a better DFS and DSS [HR 0.16; 95% confidence interval (CI) 0.04-0.64; P = 0.009 and HR 0.12; 95% CI 0.03-0.50; P = 0.004]. sHLA-G did not influence survival in cervical cancer patients, regardless of histology. We conclude that cervical adenocarcinoma patients with high sMICA levels have an increased DFS and DSS. This data warrants a prospective trial to study the functional role of sMICA in cervical adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.org/dc/terms/identifier | "doi:10.1111/tan.12562"xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Meijer D."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Jordanova E.S."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Samuels S."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Kenter G.G."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Zijlmans H.J."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "van Straalen J.P."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Buist M.R."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/author | "Ferns D.M."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/pages | "476-483"xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/title | "High levels of soluble MICA are significantly related to increased disease-free and disease-specific survival in patients with cervical adenocarcinoma."xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/25871737 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25871737 |
| http://purl.uniprot.org/citations/25871737 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0F6UUZ2-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LB88-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LB93-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LB98-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBA3-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBA6-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBB1-mappedCitation-25871737 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25871737 |