| http://purl.uniprot.org/citations/25876659 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25876659 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously demonstrated that c-Jun N-terminal kinase (JNK) phosphorylates serine 62 of Bcl-xL to induce the degradation of Bcl-xL and apoptosis in WEHI-231 cells upon BCR crosslinking. In order to elucidate the regulatory mechanisms underlying the phosphorylation of Bcl-xL, we prepared an assay system in which JNK phosphorylated Bcl-xL in HEK293T cells. Consequently, we found that a signal transduction molecule, alpha4, enhanced the phosphorylation of Bcl-xL by JNK, while the co-expression of C-terminal alpha4 (220-340) diminished the phosphorylation of Bcl-xL induced by JNK. Furthermore, full-length alpha4 associated with both JNK and Bcl-xL, whereas C-terminal alpha4 (220-340) associated only with Bcl-xL, not JNK. In addition, WEHI-231 cells transfected with the cDNA of C-terminal alpha4 (220-340) exhibited decreased phosphorylation of Bcl-xL and stronger resistance to apoptosis induced by BCR crosslinking. These results indicate that alpha4 is an important regulatory molecule of apoptosis induced by BCR crosslinking in WEHI-231 cells and that C-terminal alpha4 (220-340) functions as a dominant negative form."xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.org/dc/terms/identifier | "doi:10.2220/biomedres.36.97"xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/author | "Inui S."xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/author | "Tanabe K."xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/name | "Biomed Res"xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/pages | "97-102"xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/title | "Dominant negative form of alpha4 inhibits the BCR crosslinking-induced phosphorylation of Bcl-xL and apoptosis in an immature B cell line WEHI-231."xsd:string |
| http://purl.uniprot.org/citations/25876659 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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