| http://purl.uniprot.org/citations/25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25877925 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-12 p40, a common subunit for both IL-12 p70 and IL-23, plays a critical role in the development of Th1 and Th17 cells and autoimmune diseases. Regulation of IL-12 p40 expression is thus considered to be a strategy for developing therapies for Th1- and Th17-mediated autoimmune diseases. The mTOR protein is a subunit mTORC1 and mTORC2. Although mTORC1 has been shown to mediate IL-12 p40 expression in DCs and relevant signaling, the role of mTORC2 in IL-12 p40 expression remains largely unclear. In the present study, we demonstrate that blocking mTORC2 activity using the phytochemical cytopiloyne can specifically inhibit LPS-induced expression of IL-12 p70, IL-23, and IL-12 p40 in human DCs. This regulation by mTORC2 involving Akt activation and the persistent phase of NF-κB activation is further confirmed by siRNA knockdown of Rictor and Sin1 gene expression and the use of alternative inhibition approaches. In terms of IL-12 p40 expression, our findings reveal a new role for the mTORC2 pathway that is antagonistic to that of mTORC1. Our study provides new insight into mTOR regulation of IL-12 p40-mediated Th1 (IFN-γ) and Th17 (IL-17) responses and suggests that the phytochemical cytopiloyne might have useful applications in therapies for Th1 and Th17 cell-mediated inflammatory diseases."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.2a0414-206rr"xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Yang W.C."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Liu C.P."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Chen S.S."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Shyur L.F."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Yang N.S."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Wei W.C."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/author | "Sheu J.H."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/pages | "1071-1080"xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/title | "Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://purl.uniprot.org/core/volume | "97"xsd:string |
| http://purl.uniprot.org/citations/25877925 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25877925 |
| http://purl.uniprot.org/citations/25877925 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25877925 |
| http://purl.uniprot.org/uniprot/#_A0A0C5PS98-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TQ52-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_A1Z2L5-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_B4DZD5-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_B3KX59-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_B4E2H2-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_P42345-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |
| http://purl.uniprot.org/uniprot/#_Q9NPF7-mappedCitation-25877925 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25877925 |