| http://purl.uniprot.org/citations/25878144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25878144 | http://www.w3.org/2000/01/rdf-schema#comment | "Macroautophagy is a highly conserved intracellular bulk degradation system of all eukaryotic cells. It is governed by a large number of autophagy proteins (ATGs) and is crucial for many cellular processes. Here, we describe the phenotypes of Dictyostelium discoideum ATG16(-) and ATG9(-)/16(-) cells and compare them to the previously reported ATG9(-) mutant. ATG16 deficiency caused an increase in the expression of several core autophagy genes, among them atg9 and the two atg8 paralogues. The single and double ATG9 and ATG16 knock-out mutants had complex phenotypes and displayed severe and comparable defects in pinocytosis and phagocytosis. Uptake of Legionella pneumophila was reduced. In addition, ATG9(-) and ATG16(-) cells had dramatic defects in autophagy, development and proteasomal activity which were much more severe in the ATG9(-)/16(-) double mutant. Mutant cells showed an increase in poly-ubiquitinated proteins and contained large ubiquitin-positive protein aggregates which partially co-localized with ATG16-GFP in ATG9(-)/16(-) cells. The more severe autophagic, developmental and proteasomal phenotypes of ATG9(-)/16(-) cells imply that ATG9 and ATG16 probably function in parallel in autophagy and have in addition autophagy-independent functions in further cellular processes."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.150008"xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/author | "Steinert M."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/author | "Eichinger L."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/author | "Unal C."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/author | "Xiong Q."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/author | "Matthias J."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/name | "Open Biol"xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/pages | "150008"xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/title | "The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions."xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/25878144 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25878144 |
| http://purl.uniprot.org/citations/25878144 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25878144 |
| http://purl.uniprot.org/uniprot/O15736#attribution-97E698747E53393A900CD16AE40AC660 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/Q54NA3#attribution-97E698747E53393A900CD16AE40AC660 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/Q54NA3#attribution-C6A948D46F42895B90D4D5DC6A49BB0B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/#_Q86CR8-mappedCitation-25878144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/#_Q54NA3-mappedCitation-25878144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/#_O15736-mappedCitation-25878144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/#_Q54G11-mappedCitation-25878144 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/O15736 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/Q54NA3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25878144 |
| http://purl.uniprot.org/uniprot/Q54G11 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25878144 |