http://purl.uniprot.org/citations/25880194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/25880194 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundOverexpression of SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. In this study our primary objective is to explore the role of SLMAP gene polymorphisms in the susceptibility of type 2 diabetes (T2DM) with or without diabetic retinopathy (DR) in the Qatari population.MethodsA total of 342 Qatari subjects (non-diabetic controls and T2DM patients with or without DR) were genotyped for SLMAP gene polymorphisms (rs17058639 C > T; rs1043045 C > T and rs1057719 A > G) using Taqman SNP genotyping assay.ResultsSLMAP rs17058639 C > T polymorphism was associated with the presence of DR among Qataris with T2DM. One-way ANOVA and multiple logistic regression analysis showed SLMAP SNP rs17058639 C > T as an independent risk factor for DR development. SLMAP rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with T2DM.ConclusionsThe data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.org/dc/terms/identifier | "doi:10.1186/s12967-015-0411-6"xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Staudt M.R."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Crystal R.G."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Ding H."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Robay A."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Zirie M."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Upadhyay R."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Kiss S."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Salit J."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Abi Khalil C."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "O'Beirne S.L."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "D'Amico D.J."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "El-Shafei M."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Fakhro K."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Jayyousi A."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/author | "Tuana B."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/name | "J Transl Med"xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/pages | "61"xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/title | "Role of SLMAP genetic variants in susceptibility of diabetes and diabetic retinopathy in Qatari population."xsd:string |
http://purl.uniprot.org/citations/25880194 | http://purl.uniprot.org/core/volume | "13"xsd:string |
http://purl.uniprot.org/citations/25880194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25880194 |