| http://purl.uniprot.org/citations/25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25880195 | http://www.w3.org/2000/01/rdf-schema#comment | "Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was associated with strongly increased Jak-Stat dependent responses, but not with major differences in viral load. Genetic experiments indicate that hyperactivated Jak-Stat responses are associated with early lethality in virus-infected flies. Our results identify an essential epigenetic mechanism underlying tolerance to virus infection."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1004692"xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/author | "Schenck A."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/author | "Kramer J.M."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/author | "Overheul G.J."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/author | "Bronkhorst A.W."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/author | "Van Rij R.P."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/author | "Merkling S.H."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/pages | "e1004692"xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/title | "The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/25880195 | http://purl.uniprot.org/core/volume | "11"xsd:string |
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| http://purl.uniprot.org/citations/25880195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25880195 |
| http://purl.uniprot.org/uniprot/M9PGH7#attribution-2593382051F86642101F8622449E24C5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25880195 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LEH9-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6T9-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEI6-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4LHX7-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCQ7-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD03-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JD33-mappedCitation-25880195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25880195 |