Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25880619http://www.w3.org/2000/01/rdf-schema#comment"

Background

Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption of ELF expression resulted in miscolocalization of Smad3 and Smad4, then disruption of TGF-β signaling. However, the prognostic significance of ELF for hepatocellular carcinoma (HCC) hasn't been clarified. This study aimed to investigate whether measuring both TGF-β1 and ELF provides a more powerful predictor for HCC prognosis than either marker alone.

Methods

TGF-β1 and ELF protein were detected by immunohistochemistry. The relationship between TGF-β1/ELF expression and patients' clinicopathologic factors was analyzed. The association between TGF-β1/ELF expression and disease-free survival and overall survival was analyzed by Kaplan-Meier curves, the log-rank test, and Multivariate Cox regression analyses.

Results

The expression of TGF-β1 in HCC tissues was significantly higher than that in normal liver tissues. Conversely, the expression of ELF in HCC tissues declined markedly. ELF protein was correlated with HBsAg, tumor size, tumor number, TNM and recurrence. Data also indicated a significant negative correlation between ELF and TGF-β1. Patients with high TGF-β1 expression or/and low ELF expression appeared to have a poor postoperative disease-free survival and overall survival compared with those with low TGF-β1 expression or/and high ELF expression. Furthermore, the predictive range of ELF combined with TGF-β1 was more sensitive than that of either one alone.

Conclusions

TGF-β1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection. Our current study has demonstrated that the prognostic accuracy of testing can be enhanced by their combination."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.org/dc/terms/identifier"doi:10.1186/s12885-015-1127-y"xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Zhang L.J."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Ji F."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Fu S.J."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Li S.Q."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Liang L.J."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Cao Q.H."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Hua Y.P."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Peng B.G."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/author"Shen S.L."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/name"BMC Cancer"xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/pages"116"xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/title"The prognostic value of combined TGF-beta1 and ELF in hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/25880619http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/25880619http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25880619
http://purl.uniprot.org/citations/25880619http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25880619
http://purl.uniprot.org/uniprot/#_A0A078BBI5-mappedCitation-25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25880619
http://purl.uniprot.org/uniprot/#_A0A078BC11-mappedCitation-25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25880619
http://purl.uniprot.org/uniprot/#_A0A078BCJ0-mappedCitation-25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25880619
http://purl.uniprot.org/uniprot/#_A0A078BCH8-mappedCitation-25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25880619
http://purl.uniprot.org/uniprot/#_A0A078BFK3-mappedCitation-25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25880619
http://purl.uniprot.org/uniprot/#_A0A510GAF6-mappedCitation-25880619http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/25880619
▶