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Background

β-catenin plays a central role in multiple developmental processes. However, it has been difficult to study its pleiotropic effects, because of the dual capacity of β-catenin to coordinate cadherin-dependent cell adhesion and to act as a component of Wnt signal transduction. To distinguish between the divergent functions of β-catenin during peripheral nervous system development, we made use of a mutant allele of β-catenin that can mediate adhesion but not Wnt-induced TCF transcriptional activation. This allele was combined with various conditional inactivation approaches.

Results

We show that of all peripheral nervous system structures, only sensory dorsal root ganglia require β-catenin for proper formation and growth. Surprisingly, however, dorsal root ganglia development is independent of cadherin-mediated cell adhesion. Rather, both progenitor cell proliferation and fate specification are controlled by β-catenin signaling. These can be divided into temporally sequential processes, each of which depends on a different function of β-catenin.

Conclusions

While early stage proliferation and specific Neurog2- and Krox20-dependent waves of neuronal subtype specification involve activation of TCF transcription, late stage progenitor proliferation and Neurog1-marked sensory neurogenesis are regulated by a function of β-catenin independent of TCF activation and adhesion. Thus, switching modes of β-catenin function are associated with consecutive cell fate specification and stage-specific progenitor proliferation."xsd:string
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http://purl.uniprot.org/citations/25885041http://purl.uniprot.org/core/author"Valenta T."xsd:string
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http://purl.uniprot.org/citations/25885041http://purl.uniprot.org/core/author"Gay M.H."xsd:string
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http://purl.uniprot.org/citations/25885041http://purl.uniprot.org/core/title"Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation."xsd:string
http://purl.uniprot.org/citations/25885041http://purl.uniprot.org/core/volume"13"xsd:string
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