| http://purl.uniprot.org/citations/25886813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25886813 | http://www.w3.org/2000/01/rdf-schema#comment | "Poly(ADP-ribose) polymerase 3 (PARP3) is a member of the PARP family enzymes which catalyze the ADP-ribosylation of proteins. PARP3 plays an important role in DNA damage repair and mitotic progression. In this study, we identified, using mass spectrometric techniques, two novel post-translational modification sites in PARP3, α-N-methylation and phosphorylation of serine 461 (S461). We found that the N-terminal α-amino group of PARP3 is heavily methylated in human cells, and N-terminal RCC1 methyltransferase (NRMT) is a key enzyme required for this methylation. We also observed that the phosphorylation level of S461 in PARP3 could be reduced in human cells upon treatment with flavopiridol, a cyclin-dependent kinase inhibitor. Moreover, we demonstrated that S461 phosphorylation, but not α-N-methylation of PARP3, may be involved in the cellular response toward DNA double-strand breaks. These findings provide novel insights into the post-translational regulation of PARP3."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.org/dc/terms/identifier | "doi:10.1021/acs.jproteome.5b00126"xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/author | "Dai X."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/author | "Caldecott K.W."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/author | "You C."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/author | "Rulten S.L."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/name | "J Proteome Res"xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/pages | "2575-2582"xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/title | "Identification and Functional Characterizations of N-Terminal alpha-N-Methylation and Phosphorylation of Serine 461 in Human Poly(ADP-ribose) Polymerase 3."xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/25886813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25886813 |
| http://purl.uniprot.org/citations/25886813 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25886813 |
| http://purl.uniprot.org/uniprot/#_Q9Y6F1-mappedCitation-25886813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25886813 |
| http://purl.uniprot.org/uniprot/Q9Y6F1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25886813 |