| http://purl.uniprot.org/citations/25887157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25887157 | http://www.w3.org/2000/01/rdf-schema#comment | "Myotonic dystrophy is a neuromuscular disease of RNA toxicity. The disease gene DMPK harbors expanded CTG trinucleotide repeats on its 3'-UTR. The transcripts of this mutant DMPK led to misregulation of RNA-binding proteins including MBNL1 and Celf1. In myoblasts, CUG-expansion impaired terminal differentiation. In this study, we formally tested how the abundance of Celf1 regulates normal myocyte differentiation, and how Celf1 expression level mediates CUG-expansion RNA toxicity-triggered impairment of myocyte differentiation. As the results, overexpression of Celf1 largely recapitulated the defects of myocytes with CUG-expansion, by increasing myocyte cycling. Knockdown of endogenous Celf1 level led to precocious myotube formation, supporting a negative connection between Celf1 abundance and myocyte terminal differentiation. Finally, knockdown of Celf1 in myocyte with CUG-expansion led to partial rescue, by promoting cell cycle exit. Our results suggest that Celf1 plays a distinctive and negative role in terminal myocyte differentiation, which partially contribute to DM1 RNA toxicity. Targeting Celf1 may be a valid strategy in correcting DM1 muscle phenotypes, especially for congenital cases."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2015.04.010"xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/author | "Liang R."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/author | "Azares A.R."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/pages | "1490-1497"xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/title | "Celf1 regulates cell cycle and is partially responsible for defective myoblast differentiation in myotonic dystrophy RNA toxicity."xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://purl.uniprot.org/core/volume | "1852"xsd:string |
| http://purl.uniprot.org/citations/25887157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25887157 |
| http://purl.uniprot.org/citations/25887157 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25887157 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0T5-mappedCitation-25887157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25887157 |
| http://purl.uniprot.org/uniprot/#_P28659-mappedCitation-25887157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25887157 |
| http://purl.uniprot.org/uniprot/P28659 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25887157 |
| http://purl.uniprot.org/uniprot/A0A0R4J0T5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25887157 |