| http://purl.uniprot.org/citations/25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25891236 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumors induce the recruitment and expansion of myeloid-derived suppressor cells (MDSCs), a heterogeneous population of cells that can be further sub-divided into polymorphonuclear Ly6G(+) PMN-MDSCs and monocytic Ly6G(-) Mo-MDSCs. To identify chemokines and chemokine-related genes that are differentially expressed within the tumor microenvironment in these two MDSC subsets, we established an orthotopic hepatocellular carcinoma model in immunocompetent mice. Splenic PMN-MDSCs and Mo-MDSCs were isolated to >95% homogeneity by flow cytometry. Using a real-time PCR array, we investigated the expression of 84 genes encoding chemokines and cytokines, chemokine receptors, and related signaling molecules involved with chemotaxis. Clustering analysis suggested that a core set of chemokine-related genes is expressed in both PMN-MDSC and Mo-MDSC populations, but that the expression profile is broader for Mo-MDSCs. Furthermore, 11 genes are more highly expressed in PMN-MDSCs and 12 genes are more highly expressed in Mo-MDSCs. Among these, PMN-MDSCs express Cxcr1, Cxcr2 and Il1b at 33.03-to 109.76-fold higher levels than in Mo-MDSCs, and Mo-MDSCs express eight genes (Ccr2, Ccr5, Cmklr1, Cx3cr1, Ccr3, Ccl9, Cmtm3 and Cxcl16) at 30.2 to 515.5-fold higher levels than in PMN-MDSCs. These results suggest that the profile of chemokines and chemokine-related genes is more expansive for Mo-MDSCs than for PMN-MDSCs. The differential expression of chemokines and chemokine-associated genes may regulate the presence and activity of PMN-MDSCs and Mo-MDSCs in the tumor microenvironment."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.intimp.2015.04.010"xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Zhao B."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Zhao W."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/author | "Yin Z."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/name | "Int Immunopharmacol"xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/pages | "314-321"xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/title | "Subsets of myeloid-derived suppressor cells in hepatocellular carcinoma express chemokines and chemokine receptors differentially."xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/25891236 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25891236 |
| http://purl.uniprot.org/citations/25891236 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25891236 |
| http://purl.uniprot.org/uniprot/#_P51683-mappedCitation-25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/#_Q3TRK1-mappedCitation-25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/#_Q810W6-mappedCitation-25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/#_Q3U3U0-mappedCitation-25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/#_Q543S8-mappedCitation-25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/#_Q5ZGW9-mappedCitation-25891236 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/Q5ZGW9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25891236 |
| http://purl.uniprot.org/uniprot/P51683 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25891236 |