| http://purl.uniprot.org/citations/25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25891347 | http://www.w3.org/2000/01/rdf-schema#comment | "The release of GABA from cholecystokinin-containing interneurons is modulated by type-1 cannabinoid receptors (CB1). Here we tested the hypothesis that the strength of CB1-mediated modulation of GABA release is related to the CB1 content of axon terminals. Basket cell boutons have on average 78% higher CB1 content than those of dendritic-layer-innervating (DLI) cells, a consequence of larger bouton surface and higher CB1 density. The CB1 antagonist AM251 caused a 54% increase in action potential-evoked [Ca(2+)] in boutons of basket cells, but not in DLI cells. However, the effect of AM251 did not correlate with CB1 immunoreactivity of individual boutons. Moreover, a CB1 agonist decreased [Ca(2+)] in a cell type- and CB1-content-independent manner. Replica immunogold labelling demonstrated the colocalization of CB1 with the Cav2.2 Ca(2+) channel subunit. Our data suggest that only a subpopulation of CB1s, within nanometre distances from their target Cav2.2 channels, are responsible for endocannabinoid-mediated modulation of GABA release."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7557"xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Mate Z."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Szabo G."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Hajos N."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Holderith N."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Nusser Z."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Vizi E.S."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Kirizs T."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/author | "Lenkey N."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/pages | "6557"xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/title | "Tonic endocannabinoid-mediated modulation of GABA release is independent of the CB1 content of axon terminals."xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25891347 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25891347 |
| http://purl.uniprot.org/citations/25891347 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25891347 |
| http://purl.uniprot.org/uniprot/O55017#attribution-A74658A106EC431459CA4167989D2E35 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25891347 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWR0-mappedCitation-25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891347 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWZ5-mappedCitation-25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891347 |
| http://purl.uniprot.org/uniprot/#_F7C9S8-mappedCitation-25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891347 |
| http://purl.uniprot.org/uniprot/#_A2AIR7-mappedCitation-25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891347 |
| http://purl.uniprot.org/uniprot/#_A2AIR9-mappedCitation-25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891347 |
| http://purl.uniprot.org/uniprot/#_A2AIS0-mappedCitation-25891347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25891347 |