| http://purl.uniprot.org/citations/25892515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25892515 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic analyses have revealed an important association between P/Q-type calcium channel activities and hereditary neurological disorders. The P/Q-type channels are composed principally of heterologous multimeric subunits including CaV2.1 and CaVβ4. Of these, the β4 subunit is thought to play a significant role in channel physiology, because a mouse line mutant in that subunit (the lethargic mouse: lh) exhibits a severe ataxic phenotype. The aim of the present study was to elucidate the physiological importance of the β4 subunit. ECG analysis showed that the T wave was high in 8-week-old lh mutants; this may be associated with hyperkalemia. Upon pharmacological ECG analysis, 2-3-week-old lh mutants exhibited reduced responses to a β-blocker and a muscarinic receptor antagonist. Analysis of heart rate variability revealed that the R-R interval was unstable in lh mutants and that both the low- and high-frequency components had increased in extent, indicating that the tonus of both the sympathetic and parasympathetic nervous systems was modified. Thus, our present study revealed that the β4 subunit played a significant role in regulation of sympathetic and parasympathetic nerve activities."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2015.03.112"xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Ohba T."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Murakami M."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Ono K."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Takahashi E."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Yanagisawa T."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Sasano H."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Miyoshi I."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Kuwasako K."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Wu T.W."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/author | "Murakami A.M."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/pages | "200-205"xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/title | "Modified autonomic regulation in mice mutated in the beta4 subunit of the lh/lh calcium channel."xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://purl.uniprot.org/core/volume | "461"xsd:string |
| http://purl.uniprot.org/citations/25892515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25892515 |
| http://purl.uniprot.org/citations/25892515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25892515 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SQZ2-mappedCitation-25892515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25892515 |
| http://purl.uniprot.org/uniprot/#_A0A571BE75-mappedCitation-25892515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25892515 |
| http://purl.uniprot.org/uniprot/#_A0A571BEF0-mappedCitation-25892515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25892515 |