| http://purl.uniprot.org/citations/25893857 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25893857 | http://www.w3.org/2000/01/rdf-schema#comment | "Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for this contact inhibition using cultured vascular endothelial cells. When the cells were confluently cultured, Necl-4 was up-regulated and localized at cell-cell contact sites where it cis-interacted with the vascular endothelial growth factor (VEGF) receptor. This interaction inhibited the tyrosine-phosphorylation of the VEGF receptor through protein-tyrosine phosphatase, non-receptor type 13 (PTPN13), eventually reducing cell movement and proliferation. When the cells were sparsely cultured, Necl-4 was down-regulated but accumulated at leading edges where it inhibited the activation of Rho-associated protein kinase through PTPN13, eventually facilitating the VEGF-induced activation of Rac1 and enhancing cell movement. Necl-4 further facilitated the activation of extracellular signal-regulated kinase 1/2, eventually enhancing cell proliferation. Thus, Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0124259"xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/author | "Hirata K."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/author | "Mizutani K."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/author | "Rikitake Y."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/author | "Yamana S."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/author | "Tokiyama A."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/pages | "e0124259"xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/title | "The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation."xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/25893857 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25893857 |
| http://purl.uniprot.org/citations/25893857 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25893857 |
| http://purl.uniprot.org/uniprot/P55196#attribution-622B2D862E8969BB2E7D18C06D22283B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/Q8R464#attribution-5F52209191348FF8EC4209263C4FD847 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/Q8R464#attribution-622B2D862E8969BB2E7D18C06D22283B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/Q8NFZ8#attribution-5F52209191348FF8EC4209263C4FD847 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/Q8NFZ8#attribution-622B2D862E8969BB2E7D18C06D22283B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/Q8NFZ8#attribution-BE99C78BDD541A1EF1E45A760A9B0EEF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/P33151#attribution-5F52209191348FF8EC4209263C4FD847 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/Q12923#attribution-622B2D862E8969BB2E7D18C06D22283B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |
| http://purl.uniprot.org/uniprot/P35968#attribution-5F52209191348FF8EC4209263C4FD847 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/25893857 |