| http://purl.uniprot.org/citations/25897174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25897174 | http://www.w3.org/2000/01/rdf-schema#comment | "Viral infections and type 2 immune responses are thought to be critical for the development of chronic respiratory disease, but the link between these events needs to be better defined. Here, we study a mouse model in which infection with a mouse parainfluenza virus known as Sendai virus (SeV) leads to long-term activation of innate immune cells that drive IL-13-dependent lung disease. We find that chronic postviral disease (signified by formation of excess airway mucus and accumulation of M2-differentiating lung macrophages) requires macrophage expression of triggering receptor expressed on myeloid cells-2 (TREM-2). Analysis of mechanism shows that viral replication increases lung macrophage levels of intracellular and cell surface TREM-2, and this action prevents macrophage apoptosis that would otherwise occur during the acute illness (5-12 d after inoculation). However, the largest increases in TREM-2 levels are found as the soluble form (sTREM-2) long after clearance of infection (49 d after inoculation). At this time, IL-13 and the adapter protein DAP12 promote TREM-2 cleavage to sTREM-2 that is unexpectedly active in preventing macrophage apoptosis. The results thereby define an unprecedented mechanism for a feed-forward expansion of lung macrophages (with IL-13 production and consequent M2 differentiation) that further explains how acute infection leads to chronic inflammatory disease."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20141732"xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Jin X."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Holtzman M.J."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Colonna M."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Brett T.J."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Agapov E."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Kober D.L."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Cella M."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Patel A.C."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Byers D.E."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Alexander-Brett J."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/author | "Gilfilan S."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/pages | "681-697"xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/title | "TREM-2 promotes macrophage survival and lung disease after respiratory viral infection."xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://purl.uniprot.org/core/volume | "212"xsd:string |
| http://purl.uniprot.org/citations/25897174 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25897174 |
| http://purl.uniprot.org/citations/25897174 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25897174 |
| http://purl.uniprot.org/uniprot/#_A0A140LHP7-mappedCitation-25897174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25897174 |
| http://purl.uniprot.org/uniprot/#_A0A140LI31-mappedCitation-25897174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25897174 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA2-mappedCitation-25897174 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25897174 |