| http://purl.uniprot.org/citations/25901943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25901943 | http://www.w3.org/2000/01/rdf-schema#comment | "Identifying novel therapeutic targets for the treatment of disease is challenging. To this end, we developed a genome-wide approach of candidate gene prioritization. We independently collocated sets of genes that were implicated in rheumatoid arthritis (RA) pathogenicity through three genome-wide assays: (i) genome-wide association studies (GWAS), (ii) differentially expression in RA fibroblast-like synoviocytes (FLS), and (iii) differentially methylation in RA FLS. Integrated analysis of these complementary data sets identified a significant enrichment of multi-evidence genes (MEGs) within pathways relating to RA pathogenicity. One MEG is Engulfment and Cell Motility Protein-1 (ELMO1), a gene not previously considered as a therapeutic target in RA FLS. We demonstrated in RA FLS that ELMO1 is: (i) expressed, (ii) promotes cell migration and invasion, and (iii) regulates Rac1 activity. Thus, we created links between ELMO1 and RA pathogenicity, which in turn validates ELMO1 as a potential RA therapeutic target. This study illustrated the power of MEG-based approaches for therapeutic target identification."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0124254"xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Boyle D.L."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Firestein G.S."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Gay S."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Ball S.T."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Bartok B."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/author | "Whitaker J.W."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/pages | "e0124254"xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/title | "Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets."xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/25901943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25901943 |
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