| http://purl.uniprot.org/citations/25902538 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25902538 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation-induced cytidine deaminase (AID) is essential for antibody class switch recombination (CSR) and somatic hypermutation (SHM). AID originally was postulated to function as an RNA-editing enzyme, based on its strong homology with apolipoprotein B mRNA-editing enzyme, catalytic polypeptide 1 (APOBEC1), the enzyme that edits apolipoprotein B-100 mRNA in the presence of the APOBEC cofactor APOBEC1 complementation factor/APOBEC complementation factor (A1CF/ACF). Because A1CF is structurally similar to heterogeneous nuclear ribonucleoproteins (hnRNPs), we investigated the involvement of several well-known hnRNPs in AID function by using siRNA knockdown and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9-mediated disruption. We found that hnRNP K deficiency inhibited DNA cleavage and thereby induced both CSR and SHM, whereas hnRNP L deficiency inhibited only CSR and somewhat enhanced SHM. Interestingly, both hnRNPs exhibited RNA-dependent interactions with AID, and mutant forms of these proteins containing deletions in the RNA-recognition motif failed to rescue CSR. Thus, our study suggests that hnRNP K and hnRNP L may serve as A1CF-like cofactors in AID-mediated CSR and SHM."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1506167112"xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/author | "Hu W."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/author | "Mondal S."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/author | "Honjo T."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/author | "Begum N.A."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/author | "Stanlie A."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/pages | "5791-5796"xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/title | "Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase."xsd:string |
| http://purl.uniprot.org/citations/25902538 | http://purl.uniprot.org/core/volume | "112"xsd:string |
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