| http://purl.uniprot.org/citations/25907616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25907616 | http://www.w3.org/2000/01/rdf-schema#comment | "The poor treatment response of acute myeloid leukemia (AML) overexpressing high-risk oncogenes such as EVI1, demands specific animal models for new treatment evaluations. Evi1 is a common site of activating integrations in murine leukemia virus (MLV)-induced AML and in retroviral and lentiviral gene-modified HCS. Still, a model of overt AML induced by Evi1 has not been generated. Cell lines from MLV-induced AML are growth factor-dependent and non-transplantable. Hence, for the leukemia maintenance in the infected animals, a growth factor source such as chronic immune response has been suggested. We have investigated whether these leukemias are transplantable if provided with growth factors. We show that the Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF, acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF levels. We propose this as a general approach for modeling different forms of high-risk human AML using similar cell lines."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.org/dc/terms/identifier | "doi:10.3109/10428194.2015.1043547"xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Smith C.I."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Mohamed A.J."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Christensson B."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Gahrton G."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Dilber M.S."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Arteaga H.J."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Simonson O.E."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Moreno P.M."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Cardona M.E."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Oprea I.I."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/author | "Silva-Lara M.F."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/date | "2016"xsd:gYear |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/name | "Leuk Lymphoma"xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/pages | "183-192"xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/title | "A murine model of acute myeloid leukemia with Evi1 overexpression and autocrine stimulation by an intracellular form of GM-CSF in DA-3 cells."xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://purl.uniprot.org/core/volume | "57"xsd:string |
| http://purl.uniprot.org/citations/25907616 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25907616 |
| http://purl.uniprot.org/citations/25907616 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25907616 |
| http://purl.uniprot.org/uniprot/#_H9T841-mappedCitation-25907616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25907616 |
| http://purl.uniprot.org/uniprot/#_A4QPC8-mappedCitation-25907616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25907616 |
| http://purl.uniprot.org/uniprot/#_G3UZT5-mappedCitation-25907616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25907616 |
| http://purl.uniprot.org/uniprot/#_G3UZ13-mappedCitation-25907616 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25907616 |