| http://purl.uniprot.org/citations/25908662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25908662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25908662 | http://www.w3.org/2000/01/rdf-schema#comment | "Before chromosomes segregate into daughter cells, they align at the mitotic spindle equator, a process known as chromosome congression. Centromere-associated protein E (CENP-E)/Kinesin-7 is a microtubule plus-end-directed kinetochore motor required for congression of pole-proximal chromosomes. Because the plus-ends of many astral microtubules in the spindle point to the cell cortex, it remains unknown how CENP-E guides pole-proximal chromosomes specifically toward the equator. We found that congression of pole-proximal chromosomes depended on specific posttranslational detyrosination of spindle microtubules that point to the equator. In vitro reconstitution experiments demonstrated that CENP-E-dependent transport was strongly enhanced on detyrosinated microtubules. Blocking tubulin tyrosination in cells caused ubiquitous detyrosination of spindle microtubules, and CENP-E transported chromosomes away from spindle poles in random directions. Thus, CENP-E-driven chromosome congression is guided by microtubule detyrosination."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaa5175"xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaa5175"xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Janke C."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Janke C."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Grishchuk E.L."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Grishchuk E.L."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Magiera M.M."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Magiera M.M."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Maiato H."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Maiato H."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Tripathy S.K."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Tripathy S.K."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Barisic M."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Barisic M."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Pereira A.L."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Pereira A.L."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Silva e Sousa R."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Silva e Sousa R."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Zaytsev A.V."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/author | "Zaytsev A.V."xsd:string |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25908662 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |