| http://purl.uniprot.org/citations/25908663 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25908663 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmunity and inflammatory bowel disease (IBD), respectively. Although selection of self-specific T cells in the thymus limits responses to mammalian tissue antigens, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly understood. Here, we demonstrate that group 3 innate lymphoid cell (ILC3)-intrinsic expression of major histocompatibility complex class II (MHCII) is regulated similarly to thymic epithelial cells and that MHCII(+) ILC3s directly induce cell death of activated commensal bacteria-specific T cells. Further, MHCII on colonic ILC3s was reduced in pediatric IBD patients. Collectively, these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intestine and suggest that this process is dysregulated in human IBD."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.aaa4812"xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Dubrot J."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Hepworth M.R."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Reith W."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Farrar M.A."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Elson C.O."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Kelsen J.R."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Eberl G."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Hugues S."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "McConnell F.M."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Laufer T.M."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Withers D.R."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Baldassano R.N."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Sonnenberg G.F."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Fung T.C."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/author | "Masur S.H."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/pages | "1031-1035"xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/title | "Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells."xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://purl.uniprot.org/core/volume | "348"xsd:string |
| http://purl.uniprot.org/citations/25908663 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25908663 |
| http://purl.uniprot.org/citations/25908663 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25908663 |