| http://purl.uniprot.org/citations/25908843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25908843 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophages mediate innate immune responses that recognise foreign pathogens, and bacterial lipopolysaccharide (LPS) recruits a signalling pathway through Toll-like receptor 4 (TLR4) to induce pro-inflammatory cytokines and reactive oxygen species (ROS). LPS activation also skews the metabolism of macrophages towards a glycolytic phenotype. Here, we demonstrate that the LPS-triggered glycolytic switch is significantly attenuated in macrophages deficient for glutathione transferase omega-1 (GSTO1, note that GSTO1-1 refers to the dimeric molecule with identical type 1 subunits). In response to LPS, GSTO1-1-deficient macrophages do not produce excess lactate, or dephosphorylate AMPK, a key metabolic stress regulator. In addition, GSTO1-1-deficient cells do not induce HIF1α, which plays a key role in maintaining the pro-inflammatory state of activated macrophages. The accumulation of the TCA cycle intermediates succinate and fumarate that occurs in LPS-treated macrophages was also blocked in GSTO1-1-deficient cells. These data indicate that GSTO1-1 is required for LPS-mediated signalling in macrophages and that it acts early in the LPS-TLR4 pro-inflammatory pathway."xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.167858"xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/author | "O'Neill L.A."xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/author | "Board P.G."xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/author | "Menon D."xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/author | "Coll R."xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/pages | "1982-1990"xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/title | "GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway."xsd:string |
| http://purl.uniprot.org/citations/25908843 | http://purl.uniprot.org/core/volume | "128"xsd:string |
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