| http://purl.uniprot.org/citations/25912172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25912172 | http://www.w3.org/2000/01/rdf-schema#comment | "Defining the immune mechanisms underlying protective immunity to helminth infection remains an important challenge. Here we report that lung CD4(+) T cells and Group 2 innate lymphoid cells (ILC2s) work in concert to block Nippostrongylus brasiliensis (Nb) development in the parenchyma within 48 h in mice. Immune-damaged larvae have a striking morphological defect that is dependent on the expansion of IL-13-producing ILC2 and CD4(+) T cells, and the activation of M2 macrophages. This T-cell requirement can be bypassed by administration of IL-2 or IL-33, resulting in expansion of IL-13-producing ILC2s and larval killing. Depletion of ILC2s inhibits larval killing in IL-2-treated mice. Our results broaden understanding of ILC2's role in immunity to helminths by demonstrating that they not only act as alarmin sensors, but can also be sustained by CD4(+) T cells, ensuring both the prompt activation and the maintenance of IL-13-dependent M2 macrophage immunity in the lung."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms7970"xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Jain R."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Smith A."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Johnston K."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Painter G."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Weninger W."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Le Gros G."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Roediger B."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Ferguson P."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Bouchery T."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Camberis M."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Shepherd A."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Filbey K."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Delahunt B."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Harvie M."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Kyle R."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/author | "Forbes-Blom E."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/pages | "6970"xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/title | "ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms."xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25912172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25912172 |