| http://purl.uniprot.org/citations/25917016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25917016 | http://www.w3.org/2000/01/rdf-schema#comment | "Although nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) has been shown to contribute to osteopenia and osteoporosis which occurs in approximately 50% of neurofibromatosis type 1 (NF1) patients. Bone marrow mononuclear cells of haploinsufficient NF1 patients and Nf1(+/-) mice exhibit increased osteoclastogenesis and accelerated bone turnover; however, the culprit hematopoietic lineages responsible for perpetuating these osteolytic manifestations have yet to be elucidated. Here we demonstrate that conditional inactivation of a single Nf1 allele within the myeloid progenitor cell population (Nf1-LysM) is necessary and sufficient to promote multiple osteoclast gains-in-function, resulting in enhanced osteoclastogenesis and accelerated osteoclast bone lytic activity in response to proresorptive challenge in vivo. Surprisingly, mice conditionally Nf1 heterozygous in mature, terminally differentiated osteoclasts (Nf1-Ctsk) do not exhibit any of these skeletal phenotypes, indicating a critical requirement for Nf1 haploinsufficiency at a more primitive/progenitor stage of myeloid development in perpetuating osteolytic activity. We further identified p21Ras-dependent hyperphosphorylation of Pu.1 within the nucleus of Nf1 haploinsufficient myelomonocytic osteoclast precursors, providing a novel therapeutic target for the potential treatment of NF1 associated osteolytic manifestations."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.org/dc/terms/identifier | "doi:10.1002/jbmr.2538"xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Dong R."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Jiang L."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Peng X."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Xu M."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Menon K."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Yang F.C."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Guise T.A."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Mohammad K.S."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Rhodes S.D."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/author | "Staser K.W."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/name | "J Bone Miner Res"xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/pages | "1840-1851"xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/title | "Nf1 Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis."xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/25917016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25917016 |