| http://purl.uniprot.org/citations/25917834 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25917834 | http://www.w3.org/2000/01/rdf-schema#comment | "Expression of the G protein subunit Goα has been shown to be prominent in the atria of the rat heart and to be significantly associated with atrial natriuretic factor (ANF)-containing atrial-specific secretory granules by immunocytochemistry. In addition, differential expression profile analysis using oligonucleotide arrays has shown that the Goα isoform 1 (Goα1) is 2.3-fold more abundant in the atria than it is in the ventricles. In the present report, we show protein-protein interaction between Goα and ANF by yeast two-hybrid and by immunoprecipitation. A cardiac conditional Goα knockout model developed for the present study showed a 90% decrease in Goα expression and decreased atrial expression and ANF and brain natriuretic peptides (BNP) content. Expression of chromogranin A, a specific atrial granule core constituent, was not affected. Morphometric assessment of atrial tissue showed a very significant decrease in atrial-specific granule density as well as granule core electron density. Atrial electrical activity was not affected. The results obtained are compatible with the suggestion that Goα plays a role in ANF sorting during intracellular vectorial transport and with the presence of a mechanism that preserves the molar relationship between cellular ANF and BNP stores in the face of the decreased production of these hormones."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.org/dc/terms/identifier | "doi:10.1530/jme-15-0081"xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Hendy G.N."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Georgalis T."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "de Bold A.J."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Choudhry A."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Martinuk A."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Gollob M."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/author | "Roeske C."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/name | "J Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/pages | "277-288"xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/title | "Go protein subunit Goalpha and the secretory process of the natriuretic peptide hormones ANF and BNP."xsd:string |
| http://purl.uniprot.org/citations/25917834 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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