| http://purl.uniprot.org/citations/25921139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25921139 | http://www.w3.org/2000/01/rdf-schema#comment | "Pim kinase-3(Pim-3), a member of serine/threonine protein kinases, has been implicated in multiple human cancers and involved in Myc-induced tumorigenesis. However, little is known regarding its expression and biological function in human ovarian cancer. In this study we showed that the clinical significance and biological functions of Pim-3 in ovarian cancer and found that higher Pim-3 mRNA level are detected in ovarian cancer tissues than those in normal ovarian tissues. There are significant correlations between higher Pim-3 expression levels with the FIGO stage, histopathological subtypes, and distant metastasis in ovarian cancer patients. Lentivirus-mediated gene overexpression of Pim-3 significantly promotes the proliferation and migration of SKOV3 cell lines. Furthermore, MACC1 and Pim-3 expression were significantly correlated in human ovarian cancer cells, and overexpression of Pim-3 in ovary cancer cells increased MACC1 mRNA and protein expression. The data indicate that Pim-3 acts as a putative oncogene in ovary cancer and could be a viable diagnostic and therapeutic target for ovarian cancer."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.org/dc/terms/identifier | "doi:10.7314/apjcp.2015.16.8.3325"xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Li Y.M."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Zhuang H."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Zhao M.Y."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Yang B.C."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/author | "Hei K.W."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/name | "Asian Pac J Cancer Prev"xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/pages | "3325-3331"xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/title | "Aberrant expression of pim-3 promotes proliferation and migration of ovarian cancer cells."xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/25921139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25921139 |
| http://purl.uniprot.org/citations/25921139 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25921139 |
| http://purl.uniprot.org/uniprot/#_Q6P2J9-mappedCitation-25921139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25921139 |
| http://purl.uniprot.org/uniprot/#_Q86V86-mappedCitation-25921139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25921139 |
| http://purl.uniprot.org/uniprot/Q6P2J9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25921139 |
| http://purl.uniprot.org/uniprot/Q86V86 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25921139 |