| http://purl.uniprot.org/citations/25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25925258 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of the epithelial Na(+) channel (ENaC) reduces Cl(-) absorption in cortical collecting ducts (CCDs) from aldosterone-treated rats and mice. Since ENaC does not transport Cl(-), the purpose of the present study was to explore how ENaC modulates Cl(-) absorption in mouse CCDs perfused in vitro. Therefore, we measured transepithelial Cl(-) flux and transepithelial voltage in CCDs perfused in vitro taken from mice that consumed a NaCl-replete diet alone or the diet with aldosterone administered by minipump. We observed that application of an ENaC inhibitor [benzamil (3 μM)] to the luminal fluid unmasks conductive Cl(-) secretion. During ENaC blockade, this Cl(-) secretion fell with the application of a nonselective Cl(-) channel blocker [DIDS (100 μM)] to the perfusate. While single channel recordings of intercalated cell apical membranes in split-open CCDs demonstrated a Cl(-) channel with properties that resemble the ClC family of Cl(-) channels, ClC-5 is not the primary pathway for benzamil-sensitive Cl(-) flux. In conclusion, first, in CCDs from aldosterone-treated mice, most Cl(-) absorption is benzamil sensitive, and, second, benzamil application stimulates stilbene-sensitive conductive Cl(-) secretion, which occurs through a ClC-5-independent pathway."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajprenal.00471.2013"xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Eaton D.C."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Verlander J.W."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Wall S.M."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Pech V."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Weinstein A.M."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Bao H.F."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Nanami M."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Agazatian D."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/author | "Lazo-Fernandez Y."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/name | "Am J Physiol Renal Physiol"xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/pages | "F251-8"xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/title | "ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion."xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://purl.uniprot.org/core/volume | "309"xsd:string |
| http://purl.uniprot.org/citations/25925258 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25925258 |
| http://purl.uniprot.org/citations/25925258 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25925258 |
| http://purl.uniprot.org/uniprot/#_B1ATV1-mappedCitation-25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25925258 |
| http://purl.uniprot.org/uniprot/#_H3BJC3-mappedCitation-25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25925258 |
| http://purl.uniprot.org/uniprot/#_H3BLI2-mappedCitation-25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25925258 |
| http://purl.uniprot.org/uniprot/#_H3BKC4-mappedCitation-25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25925258 |
| http://purl.uniprot.org/uniprot/#_H3BKP2-mappedCitation-25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25925258 |
| http://purl.uniprot.org/uniprot/#_H3BKW1-mappedCitation-25925258 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25925258 |