| http://purl.uniprot.org/citations/25926139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25926139 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitofusin-2 (Mfn-2) is a hyperplasia suppressor. Changes in Mfn-2 expression are thought to reflect mitochondrial remodeling during cell proliferation. However, it is unclear how the participation of Mfn-2 in mitochondrial remodeling prevents cellular proliferation. Here we show that arresting vascular smooth muscle cells (VSMCs) in the G0/G1 phase by serum starvation up-regulates Mfn-2 expression and causes mitochondria to assemble into a tubular network and to attach to the endoplasmic reticulum (ER). In the S phase, short rod-shaped mitochondrial structures that were dissociated from the ER were observed. Levels of glucose, ATP, l-amino acid, and NADP(+) did not vary throughout the cell cycle. However, NAD(+) level was lower and NADH level was higher in the G0/G1 phase than in the S phase. Mitochondrial membrane potential was lower in the S phase than in the G0/G1 phase. Infecting VSMCs with an adenovirus encoding full-length Mfn-2 increased NADH level and reduced NAD(+) level, while infecting the cells with an adenovirus that silences the p21(ras) signature motif produced opposite effects. These results suggest that Mfn-2 up-regulation causes mitochondrial fusion into tubular networks and attachment to the ER, which in turn halts proliferation of VSMCs."xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.org/dc/terms/identifier | "doi:10.1093/abbs/gmv035"xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/author | "Guan Y."xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/name | "Acta Biochim Biophys Sin (Shanghai)"xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/pages | "441-450"xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/title | "Mitofusin-2-mediated tethering of mitochondria and endoplasmic reticulum promotes cell cycle arrest of vascular smooth muscle cells in G0/G1 phase."xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://purl.uniprot.org/core/volume | "47"xsd:string |
| http://purl.uniprot.org/citations/25926139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25926139 |
| http://purl.uniprot.org/citations/25926139 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25926139 |
| http://purl.uniprot.org/uniprot/#_A0A8J8XEU2-mappedCitation-25926139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25926139 |
| http://purl.uniprot.org/uniprot/#_Q6IRL2-mappedCitation-25926139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25926139 |
| http://purl.uniprot.org/uniprot/#_Q8R500-mappedCitation-25926139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25926139 |
| http://purl.uniprot.org/uniprot/A0A8J8XEU2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25926139 |
| http://purl.uniprot.org/uniprot/Q6IRL2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25926139 |
| http://purl.uniprot.org/uniprot/Q8R500 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25926139 |