| http://purl.uniprot.org/citations/2592769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2592769 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-2-independent CD8+ rat x BW5147 T cell hybridomas are highly sensitive to treatment with 10(-6) M dexamethasone. This glucocorticoid analog induces a rapid DNA fragmentation with a pattern similar to that observed during glucocorticoid-induced killing of mouse thymocytes, which suggests the activation of a similar specific endonuclease. Among these hybrids, we select variants expressing low affinity IL-2R, as measured by IL-2 binding assay and by the cell surface expression of the IL-2Rp55 Ag (rat CD25 recognized by OX-39 mAb). These OX-39+ IL-2 independent hybrids (named V type) are protected from the toxic action of dexamethasone by IL-2. The addition of IL-2 to V type cells induces the expression of a low number of high affinity IL-2R, which is strongly potentiated by the simultaneous addition of dexamethasone. Furthermore, dexamethasone is strongly synergistic with IL-2 in the induction of mRNA p55/IL-2R, which could be observed 6 h after the treatment. These data suggest that the utilization of the IL-2-R signaling pathway may induce an effective protection against glucocorticoid toxicity in mature T cells. Finally, we proved that the upregulation of IL-2R by IL-2 is strongly potentiated by glucocorticoids, which implies a new role for these agents in the immune system."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Silva A."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Sanz E."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Rebollo A."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Fernandez-Ruiz E."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Somoza C."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Nieto M.A."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Ramirez F."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/author | "Lopez-Rivas A."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/date | "1989"xsd:gYear |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/pages | "4146-4151"xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/title | "IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors."xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://purl.uniprot.org/core/volume | "143"xsd:string |
| http://purl.uniprot.org/citations/2592769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2592769 |
| http://purl.uniprot.org/citations/2592769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2592769 |
| http://purl.uniprot.org/uniprot/P26897#attribution-789A12A7578D3B5F2894E67D4B7BE3BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/2592769 |
| http://purl.uniprot.org/uniprot/#_P26897-mappedCitation-2592769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2592769 |
| http://purl.uniprot.org/uniprot/P26897 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2592769 |