| http://purl.uniprot.org/citations/25931121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25931121 | http://www.w3.org/2000/01/rdf-schema#comment | "Voltage-dependent calcium channels (Cav) of the T-type family (Cav3.1, Cav3.2, and Cav3.3) are activated by low threshold membrane depolarization and contribute greatly to neuronal network excitability. Enhanced T-type channel activity, especially Cav3.2, contributes to disease states, including absence epilepsy. Interestingly, the intracellular loop connecting domains I and II (I-II loop) of Cav3.2 channels is implicated in the control of both surface expression and channel gating, indicating that this I-II loop plays an important regulatory role in T-type current. Here we describe that co-expression of this I-II loop or its proximal region (Δ1-Cav3.2; Ser(423)-Pro(542)) together with recombinant full-length Cav3.2 channel inhibited T-type current without affecting channel expression and membrane incorporation. Similar T-type current inhibition was obtained in NG 108-15 neuroblastoma cells that constitutively express Cav3.2 channels. Of interest, Δ1-Cav3.2 inhibited both Cav3.2 and Cav3.1 but not Cav3.3 currents. Efficacy of Δ1-Cav3.2 to inhibit native T-type channels was assessed in thalamic neurons using viral transduction. We describe that T-type current was significantly inhibited in the ventrobasal neurons that express Cav3.1, whereas in nucleus reticularis thalami neurons that express Cav3.2 and Cav3.3 channels, only the fast inactivating T-type current (Cav3.2 component) was significantly inhibited. Altogether, these data describe a new strategy to differentially inhibit Cav3 isoforms of the T-type calcium channels."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m114.634261"xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Lory P."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Mezghrani A."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Monteil A."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Blesneac I."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Lambert R.C."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Lemmers C."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Huc-Brandt S."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Boutourlinsky K."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Leresche N."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Bidaud I."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/author | "Chausson P."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/pages | "16168-16176"xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/title | "Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop."xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/25931121 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25931121 |
| http://purl.uniprot.org/citations/25931121 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25931121 |
| http://purl.uniprot.org/uniprot/#_A0A1W2PQW2-mappedCitation-25931121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25931121 |
| http://purl.uniprot.org/uniprot/#_A2SX35-mappedCitation-25931121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25931121 |
| http://purl.uniprot.org/uniprot/#_A2SX36-mappedCitation-25931121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25931121 |
| http://purl.uniprot.org/uniprot/#_A2SX37-mappedCitation-25931121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25931121 |