| http://purl.uniprot.org/citations/25936916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25936916 | http://www.w3.org/2000/01/rdf-schema#comment | "Maintaining genomic integrity is of paramount importance to embryonic stem cells (ESCs), as mutations are readily propagated to daughter cells. ESCs display hypersensitivity to DNA damage-induced apoptosis (DIA) to prevent such propagation, although the molecular mechanisms underlying this apoptotic response are unclear. Here, we report that the regulatory RNA Apela positively regulates p53-mediated DIA. Apela is highly expressed in mouse ESCs and is repressed by p53 activation, and Apela depletion compromises p53-dependent DIA. Although Apela contains a coding region, this coding ability is dispensable for Apela's role in p53-mediated DIA. Instead, Apela functions as a regulatory RNA and interacts with hnRNPL, which prevents the mitochondrial localization and activation of p53. Together, these results describe a tri-element negative feedback loop composed of p53, Apela, and hnRNPL that regulates p53-mediated DIA, and they further demonstrate that regulatory RNAs add a layer of complexity to the apoptotic response of ESCs after DNA damage."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2015.04.002"xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Jiang S."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Lei M."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Shi J."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Zhou M."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Huang J.'"xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Gou H."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Dubois W."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Tripathi B.K."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/author | "Waybright T."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/pages | "669-683"xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/title | "An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells."xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/25936916 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25936916 |
| http://purl.uniprot.org/citations/25936916 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25936916 |
| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-25936916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25936916 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-25936916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25936916 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-25936916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25936916 |
| http://purl.uniprot.org/uniprot/#_A5JTV6-mappedCitation-25936916 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25936916 |