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http://purl.uniprot.org/citations/25937534http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/25937534http://www.w3.org/2000/01/rdf-schema#comment"Smooth muscle (SM) 22α, an actin-binding protein, is down-regulated in atherosclerotic arteries. Disruption of SM22α promotes arterial inflammation through activation of reactive oxygen species (ROS)-mediated nuclear factor (NF)-κB pathways. This study aimed to investigate the mechanisms by which SM22α regulates vascular inflammatory response. The ligation injury model of SM22α(-/-) mice displayed up-regulation of inflammatory molecules MCP-1, VCAM-1, and ICAM-1 in the carotid arteries. Similar results were discovered in human atherosclerotic samples. In vitro studies, overexpression of SM22α attenuated TNF-α-induced IκBα phosphorylation and degradation, accompanied by decreased NF-κB activity and reduced inflammatory molecule expression. Using coimmunoprecipitation, we found that SM22α interacted with and stabilized IκBα in quiescent VSMCs. Upon TNF-α stimulation, SM22α was phosphorylated by casein kinase (CK) II at Thr139, leading to dissociation of SM22α from IκBα, followed by IκBα degradation and NF-κB activation. Our findings demonstrate that SM22α is a phosphorylation-regulated suppressor of IKK-IκBα-NF-κB signaling cascades. SM22α may be a novel therapeutic target for human vascular diseases and other inflammatory conditions."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.org/dc/terms/identifier"doi:10.1016/j.yjmcc.2015.04.020"xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Chen R."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Han M."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Li H."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Zhang F."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Bi W."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Xie X.L."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Lin Y.L."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Zhang D.D."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Lv P."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Zhao L.L."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Dong L.H."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Miao S.B."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Shu Y.N."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/author"Xue Z.Y."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/name"J Mol Cell Cardiol"xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/pages"191-199"xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/title"SM22alpha inhibits vascular inflammation via stabilization of IkappaBalpha in vascular smooth muscle cells."xsd:string
http://purl.uniprot.org/citations/25937534http://purl.uniprot.org/core/volume"84"xsd:string
http://purl.uniprot.org/citations/25937534http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25937534
http://purl.uniprot.org/citations/25937534http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/25937534
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