| http://purl.uniprot.org/citations/25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25940993 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we typed 930 cases of nasopharyngeal carcinoma (NPC) and 1134 normal controls recruited from Hunan province, southern China for human leukocyte antigen-A (HLA-A) locus by sequencing exons 2-4. Very significant associations between HLA-A*02:07, HLA-A*11:01 and NPC were established [25.7% vs 16.18%; odds ratio, OR (95% confidence interval, CI) = 1.79 (1.54-2.09), P < 0.0001 and 21.1% vs 30.42%, OR (95% CI) = 0.61 (0.53-0.70), P<0.0001, respectively]. Further analysis of the molecular basis underlying these associations suggests that cysteine (C) at codon 99 of α2-helix of HLA-A protein is probably deleterious and confers risk to NPC. Convincing evidence was uncovered for negative association of a rare allele in southern Chinese populations, HLA-A*31:01, with NPC [0.22% vs 2.12%, OR (95% CI) = 0.1 (0.04-0.28), P < 0.0001]. rs1059449-A, which encodes arginine (R) at codon 56 of α1-helix of HLA-A protein, was postulated to be crucial for such a pattern of negative association with NPC. A subset of NPC cases (N = 632) and normal controls (N=712) were tested for anti-virus capsid antigen (anti-VCA) immunoglobulin A (IgA), very significant difference in seropositivity for anti-VCA IgA was observed between the two groups [67.56% vs 6.46%, OR (95% CI) = 30.16 (21.42-42.46), P < 0.0001]. However, seropositivity for anti-VCA IgA did not correlate with HLA-A allelic typing in both groups."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.org/dc/terms/identifier | "doi:10.1111/tan.12576"xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Wang W.Y."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Tian W."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Liu K.L."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Li L.X."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Jin H.K."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Zhu F.M."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/author | "Cai J.H."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/name | "Tissue Antigens"xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/pages | "15-20"xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/title | "Sequence-based typing of HLA-A gene in 930 patients with nasopharyngeal carcinoma in Hunan province, southern China."xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/25940993 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25940993 |
| http://purl.uniprot.org/citations/25940993 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25940993 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25940993 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25940993 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25940993 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25940993 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25940993 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-25940993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25940993 |