| http://purl.uniprot.org/citations/25941374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25941374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25941374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25941374 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanisms underlying pathogen emergence in humans is a critical but poorly understood area of microbiologic investigation. Serotype V group B Streptococcus (GBS) was first isolated from humans in 1975, and rates of invasive serotype V GBS disease significantly increased starting in the early 1990s. We found that 210 of 229 serotype V GBS strains (92%) isolated from the bloodstream of nonpregnant adults in the United States and Canada between 1992 and 2013 were multilocus sequence type (ST) 1. Elucidation of the complete genome of a 1992 ST-1 strain revealed that this strain had the highest homology with a GBS strain causing cow mastitis and that the 1992 ST-1 strain differed from serotype V strains isolated in the late 1970s by acquisition of cell surface proteins and antimicrobial resistance determinants. Whole-genome comparison of 202 invasive ST-1 strains detected significant recombination in only eight strains. The remaining 194 strains differed by an average of 97 SNPs. Phylogenetic analysis revealed a temporally dependent mode of genetic diversification consistent with the emergence in the 1990s of ST-1 GBS as major agents of human disease. Thirty-one loci were identified as being under positive selective pressure, and mutations at loci encoding polysaccharide capsule production proteins, regulators of pilus expression, and two-component gene regulatory systems were shown to affect the bacterial phenotype. These data reveal that phenotypic diversity among ST-1 GBS is mainly driven by small genetic changes rather than extensive recombination, thereby extending knowledge into how pathogens adapt to humans."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1504725112"xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1504725112"xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1504725112"xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Grandi G."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Grandi G."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Grandi G."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Petrosino J.F."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Petrosino J.F."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Petrosino J.F."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Yao H."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Yao H."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Yao H."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Rappuoli R."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Rappuoli R."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Rappuoli R."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Su X."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Holder M.E."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Holder M.E."xsd:string |
| http://purl.uniprot.org/citations/25941374 | http://purl.uniprot.org/core/author | "Holder M.E."xsd:string |