| http://purl.uniprot.org/citations/25942454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25942454 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer cells display aneuploid karyotypes and typically mis-segregate chromosomes at high rates, a phenotype referred to as chromosomal instability (CIN). To test the effects of aneuploidy on chromosome segregation and other mitotic phenotypes we used the colorectal cancer cell line DLD1 (2n = 46) and two variants with trisomy 7 or 13 (DLD1+7 and DLD1+13), as well as euploid and trisomy 13 amniocytes (AF and AF+13). We found that trisomic cells displayed higher rates of chromosome mis-segregation compared to their euploid counterparts. Furthermore, cells with trisomy 13 displayed a distinctive cytokinesis failure phenotype. We showed that up-regulation of SPG20 expression, brought about by trisomy 13 in DLD1+13 and AF+13 cells, is sufficient for the cytokinesis failure phenotype. Overall, our study shows that aneuploidy can induce chromosome mis-segregation. Moreover, we identified a trisomy 13-specific mitotic phenotype that is driven by up-regulation of a gene encoded on the aneuploid chromosome."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.05068"xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Cimini D."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Ried T."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Logarinho E."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Lima V."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Macedo J.C."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Nicholson J.M."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Wangsa D."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Camps J."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Gomes A.M."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Doria S."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/author | "Mattingly A.J."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/title | "Chromosome mis-segregation and cytokinesis failure in trisomic human cells."xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/25942454 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25942454 |
| http://purl.uniprot.org/citations/25942454 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25942454 |
| http://purl.uniprot.org/uniprot/#_A0A024RDV9-mappedCitation-25942454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25942454 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z510-mappedCitation-25942454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25942454 |
| http://purl.uniprot.org/uniprot/#_A8K6Q9-mappedCitation-25942454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25942454 |
| http://purl.uniprot.org/uniprot/#_B3KMI3-mappedCitation-25942454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25942454 |
| http://purl.uniprot.org/uniprot/#_B3KML8-mappedCitation-25942454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25942454 |