| http://purl.uniprot.org/citations/25944909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25944909 | http://www.w3.org/2000/01/rdf-schema#comment | "Non-thyroidal illness syndrome (NTIS), characterized by low serum 3,5,3'-triiodothyronine (T3) with normal l-thyroxine (T4) levels, is associated with malignancy. Decreased activity of type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes to NTIS. T3 binds to thyroid hormone receptor, which heterodimerizes with retinoid X receptor (RXR) and regulates transcription of target genes, such as DIO1. NF-κB activation by inflammatory cytokines inhibits DIO1 expression. The oncogene astrocyte elevated gene-1 (AEG-1) inhibits RXR-dependent transcription and activates NF-κB. Here, we interrogated the role of AEG-1 in NTIS in the context of hepatocellular carcinoma (HCC). T3-mediated gene regulation was analyzed in human HCC cells, with overexpression or knockdown of AEG-1, and primary hepatocytes from AEG-1 transgenic (Alb/AEG-1) and AEG-1 knock-out (AEG-1KO) mice. Serum T3 and T4 levels were checked in Alb/AEG-1 mice and human HCC patients. AEG-1 and DIO1 levels in human HCC samples were analyzed by immunohistochemistry. AEG-1 inhibited T3-mediated gene regulation in human HCC cells and mouse hepatocytes. AEG-1 overexpression repressed and AEG-1 knockdown induced DIO1 expression. An inverse correlation was observed between AEG-1 and DIO1 levels in human HCC patients. Low T3 with normal T4 was observed in the sera of HCC patients and Alb/AEG-1 mice. Inhibition of co-activator recruitment to RXR and activation of NF-κB were identified to play a role in AEG-1-mediated down-regulation of DIO1. AEG-1 thus might play a role in NTIS associated with HCC and other cancers."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m115.649707"xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Mas V."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Emdad L."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Fisher P.B."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Sarkar D."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Srivastava J."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Siddiq A."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Rajasekaran D."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Robertson C.L."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Mukhopadhyay N.D."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Gredler R."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/author | "Akiel M.A."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/pages | "15549-15558"xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/title | "Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC)."xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/25944909 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25944909 |
| http://purl.uniprot.org/citations/25944909 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25944909 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRF4-mappedCitation-25944909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25944909 |
| http://purl.uniprot.org/uniprot/#_E9PUX0-mappedCitation-25944909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25944909 |
| http://purl.uniprot.org/uniprot/#_F6QFT1-mappedCitation-25944909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25944909 |
| http://purl.uniprot.org/uniprot/#_F6QHD1-mappedCitation-25944909 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25944909 |