| http://purl.uniprot.org/citations/25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25945837 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that IGF binding protein-3 (IGFBP-3), a major IGF-binding protein in human serum, regulates angiogenic activities of human head and neck squamous cell carcinoma (HNSCC) cells and human umbilical vein endothelial cells (HUVECs) through IGF-dependent and IGF-independent mechanisms. However, the role of IGFBP-3 in cell adhesion is largely unknown. We demonstrate here that IGFBP-3 inhibits the adhesion of HNSCC cells and HUVECs to the extracellular matrix (ECM). IGFBP-3 reduced transcription of a variety of integrins, especially integrin β4, and suppressed phosphorylation of focal adhesion kinase (FAK) and Src in these cells through both IGF-dependent and IGF-independent pathways. IGFBP-3 was found to suppress the transcription of c-fos and c-jun and the activity of AP1 transcription factor. The regulatory effect of IGFBP-3 on integrin β4 transcription was attenuated by blocking c-jun and c-fos gene expression via siRNA transfection. Taken together, our data show that IGFBP-3 has IGF-dependent and -independent inhibitory effects on intracellular adhesion signaling in HNSCC and HUVECs through its ability to block c-jun and c-fos transcription and thus AP-1-mediated integrin β4 transcription. Collectively, our data suggest that IGFPB-3 may be an effective cancer therapeutic agent by blocking integrin-mediated adhesive activity of tumor and vascular endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.org/dc/terms/identifier | "doi:10.18632/oncotarget.3825"xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/author | "Lee H.Y."xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/author | "Lee H.J."xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/author | "Hwang S.J."xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/name | "Oncotarget"xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/pages | "15150-15163"xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/title | "Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin beta4 expression."xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/25945837 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25945837 |
| http://purl.uniprot.org/citations/25945837 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25945837 |
| http://purl.uniprot.org/uniprot/#_B3KRZ1-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B3KRJ8-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B3KVF9-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_A6XNC9-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
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| http://purl.uniprot.org/uniprot/#_A6XND1-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B4DP07-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B4DN53-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B7ZLD5-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B7ZLD8-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |
| http://purl.uniprot.org/uniprot/#_B3KPF0-mappedCitation-25945837 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25945837 |