| http://purl.uniprot.org/citations/25948251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25948251 | http://www.w3.org/2000/01/rdf-schema#comment | "Photoreceptor degeneration in age-related macular degeneration (AMD) is associated with an infiltration and chronic accumulation of mononuclear phagocytes (MPs). We have previously shown that Cx3cr1-deficient mice develop age- and stress-related subretinal accumulation of MPs, which is associated with photoreceptor degeneration. Cx3cr1-deficient MPs have been shown to increase neuronal apoptosis through IL-1β in neuroinflammation of the brain. The reason for increased IL-1β secretion from Cx3cr1-deficient MPs, and whether IL-1β is responsible for increased photoreceptor apoptosis in Cx3cr1-deficient mice, has not been elucidated. Here we show that Cx3cr1-deficient MPs express increased surface P2X7 receptor (P2RX7), which stimulates IL-1β maturation and secretion. P2RX7 and IL-1β inhibition efficiently blunted Cx3cr1-MP-dependent photoreceptor apoptosis in a monocyte/retina coculture system and in light-induced subretinal inflammation of Cx3cr1-deficient mice in vivo. Our results provide an explanation for increased CX3CR1-dependent IL-1β secretion and suggest that IL-1β or P2RX7 inhibition can help inhibit the inflammation-associated photoreceptor cell loss in late AMD, including geographic atrophy, for which no efficient treatment currently exists."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3955-14.2015"xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Levy O."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Sahel J.A."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Paques M."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Lavalette S."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Sennlaub F."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Guillonneau X."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Delarasse C."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Hu S.J."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Calippe B."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Housset M."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Montassar F."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/author | "Roubeix C."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/pages | "6987-6996"xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/title | "Upregulation of P2RX7 in Cx3cr1-Deficient Mononuclear Phagocytes Leads to Increased Interleukin-1beta Secretion and Photoreceptor Neurodegeneration."xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/25948251 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25948251 |
| http://purl.uniprot.org/citations/25948251 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25948251 |
| http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-25948251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25948251 |
| http://purl.uniprot.org/uniprot/#_A0AA51YZX7-mappedCitation-25948251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25948251 |
| http://purl.uniprot.org/uniprot/#_A2VCP3-mappedCitation-25948251 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25948251 |