| http://purl.uniprot.org/citations/25953661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25953661 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin A nephropathy (IgAN) is characterized by a qualitative abnormality of IgA in the circulation and IgA deposition in the renal mesangium. Recent research has indicated that pathogenic IgA may originate from affected tonsils. Follicular dendritic cell-secreted protein (FDC-SP), a small novel secretory protein that may regulate the induction of B-cell responses, has been suggested to control IgA production. Given this background, this study investigated the expression of FDC-SP and its correlation with IgA production in the tonsils of IgAN patients. Immunohistochemistry and reverse transcription-polymerase chain reaction were used to compare the expression of FDC-SP in the tonsils of IgAN patients with tonsillitis and of non-IgAN patients with chronic tonsillitis. The location of FDC-SP in tonsillar tissue was confirmed by double immunofluorescence. We found that FDC-SP expression significantly decreased and was correlated negatively with enhanced IgA production in the tonsils of IgAN patients. FDC-SP secreted by follicular dendritic cells may act on germinal center B cells and participate in the modulation of IgA generation in the tonsils. Our study demonstrated that FDC-SP may be involved in IgA production in the tonsils of IgAN patients, making this protein an attractive candidate immunomodulator, and highlighting a promising strategy for therapeutic intervention in IgAN."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.trsl.2015.04.004"xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Ohta N."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Kato T."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Ye F."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Yamakawa M."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Yu X.Y."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Li H.N."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Ishida A."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Yang S.R."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Jin X.M."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Meng H.X."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Kakehata S."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Geng J.S."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "E X.Q."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Geng J.S.'"xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/author | "Ohe R."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/name | "Transl Res"xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/pages | "281-291"xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/title | "Decreased expression of follicular dendritic cell-secreted protein correlates with increased immunoglobulin A production in the tonsils of individuals with immunoglobulin A nephropathy."xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://purl.uniprot.org/core/volume | "166"xsd:string |
| http://purl.uniprot.org/citations/25953661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25953661 |