| http://purl.uniprot.org/citations/25955970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25955970 | http://www.w3.org/2000/01/rdf-schema#comment | "The final identity of a differentiated neuron is determined by multiple signaling events, including activity dependent calcium transients. Non-canonical Frizzled2 (Fz2) signaling generates calcium transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developing vertebrate brain. Here, we demonstrate a requirement for Fz2/Ca(2+) signaling in determining the final differentiated state of a set of central brain dopaminergic neurons in Drosophila, referred to as the protocerebral anterior medial (PAM) cluster. Knockdown or inhibition of Fz2/Ca(2+) signaling during maturation of the flight circuit in pupae reduces Tyrosine Hydroxylase (TH) expression in the PAM neurons and affects maintenance of flight. Thus, we demonstrate that Fz2/Ca(2+) transients during development serve as a pre-requisite for normal adult behavior. Our results support a neural mechanism where PAM neuron send projections to the α' and β' lobes of a higher brain centre, the mushroom body, and function in dopaminergic re-inforcement of flight."xsd:string |
| http://purl.uniprot.org/citations/25955970 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.07046"xsd:string |
| http://purl.uniprot.org/citations/25955970 | http://purl.uniprot.org/core/author | "Hasan G."xsd:string |
| http://purl.uniprot.org/citations/25955970 | http://purl.uniprot.org/core/author | "Agrawal T."xsd:string |
| http://purl.uniprot.org/citations/25955970 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25955970 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/25955970 | http://purl.uniprot.org/core/title | "Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca^2⁺ signaling."xsd:string |
| http://purl.uniprot.org/citations/25955970 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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