| http://purl.uniprot.org/citations/25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25959868 | http://www.w3.org/2000/01/rdf-schema#comment | "Mechanically-induced skeletal muscle growth is regulated by mammalian/mechanistic target of rapamycin complex 1 (mTORC1). Yes-Associated Protein (YAP) is a mechanically-sensitive, and growth-related, transcriptional co-activator that can regulate mTORC1. Here we show that, in skeletal muscle, mechanical overload promotes an increase in YAP expression; however, the time course of YAP expression is markedly different from that of mTORC1 activation. We also show that the overexpression of YAP induces hypertrophy via an mTORC1-independent mechanism. Finally, we provide preliminary evidence of possible mediators of YAP-induced hypertrophy (e.g. increased MyoD and c-Myc expression, and decreased Smad2/3 activity and muscle ring finger 1 (MuRF1) expression)."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2015.04.047"xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/author | "Jacobs B.L."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/author | "Hornberger T.A."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/author | "You J.S."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/author | "McNally R.M."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/author | "Goodman C.A."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/author | "Dietz J.M."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/pages | "1491-1497"xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/title | "Yes-Associated Protein is up-regulated by mechanical overload and is sufficient to induce skeletal muscle hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://purl.uniprot.org/core/volume | "589"xsd:string |
| http://purl.uniprot.org/citations/25959868 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25959868 |
| http://purl.uniprot.org/citations/25959868 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25959868 |
| http://purl.uniprot.org/uniprot/#_G3UY62-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/#_G3UYA6-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/#_G3UYV4-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/#_G3UYW7-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/#_P46938-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/#_Q3TUW1-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/#_Q3U046-mappedCitation-25959868 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/G3UYW7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25959868 |
| http://purl.uniprot.org/uniprot/Q3U046 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/25959868 |