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http://purl.uniprot.org/citations/25963168http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Background

Previous studies have suggested the abnormal expression of soluble B7-H4 (sB7-H4) in circulation in cancer patients. The aim of present study was to examine the sB7-H4 expression in serum and to investigate the correlations between sB7-H4 levels and clinicopathologic parameters as well as the survival rate of patients with hepatocellular carcinoma (HCC).

Materials and methods

Circulating sB7-H4 levels in blood specimens from 93 patients with HCC and 55 healthy volunteers were examined by enzyme-linked immunosorbent assay. The association of sB7-H4 levels with clinicopathologic factors, overall survival (OS), and time to recurrence were statistically analyzed.

Results

sB7-H4 levels in HCC patients were significantly higher than that in healthy controls (49.12 ± 3.10 versus 31.66 ± 2.59 ng/mL, P < 0.001). High sB7-H4 levels were correlated with tumor size (P = 0.007), tumor invasion (P = 0.037), tumor differentiation (P = 0.044) and tumor-node metastasis stage (P < 0.001). In addition, high sB7-H4 levels were significantly related to poor OS and higher recurrence probability (P = 0.002, P = 0.014, respectively). High sB7-H4 levels were independent prognostic factors for both OS (hazard ratio = 2.497; 95% confidence interval, 1.133-3.789; P = 0.009) and time to recurrence (hazard ratio = 2.33; 95% confidence interval, 1.247-4.179; P = 0.008).

Conclusions

Detection of sB7-H4 in serum might serve as a clinical predictor in the diagnosis or prediction of clinical outcomes for the patients with HCC."xsd:string
http://purl.uniprot.org/citations/25963168http://purl.org/dc/terms/identifier"doi:10.1016/j.jss.2015.04.034"xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/date"2015"xsd:gYear
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/name"J Surg Res"xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/pages"301-306"xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/title"Diagnostic value of serum B7-H4 for hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/25963168http://purl.uniprot.org/core/volume"197"xsd:string
http://purl.uniprot.org/citations/25963168http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/25963168
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