| http://purl.uniprot.org/citations/25966234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25966234 | http://www.w3.org/2000/01/rdf-schema#comment | "We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+) group and a CA(-) group. A control group comprised 100 healthy people from the medical examination center of the same hospital. Genomic DNA from all the subjects was isolated by phenol-chloroform extraction and target genes were amplified using sequence-specific primer-polymerase chain reaction, followed by gene type detection of HPA. There were significant differences in allele and genotype frequencies of HPA-1, -2, -3, and -5 among the three groups [CA(+), CA(-), and the control group] (P < 0.05), and significant differences in allele and genotype frequencies of HPA-1, -2, and -3 between groups CA(+) and CA(-) and the control group (P < 0.05). Moreover, there was a significant difference in allele and genotype frequencies of HPA-5 between the CA(+) and CA(-) groups (P < 0.05). Logistic regression analysis showed that risk factors for T2DM patients developing a CA complication were age, duration of diabetes, high blood pressure, smoking, overweight, abnormal blood lipid levels, and polymorphism of HPA-5. There may be a correlation between T2DM and polymorphism of HPA-1-3. Polymorphism of HPA-5 is probably a risk factor for CA complicating T2DM."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.org/dc/terms/identifier | "doi:10.4238/2015.may.4.19"xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/author | "Hong H.S."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/author | "Zheng J."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/author | "Fan L.M."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/author | "Zhang Y.H."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/author | "Xu S.F."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/name | "Genet Mol Res"xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/pages | "4607-4615"xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/title | "Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population."xsd:string |
| http://purl.uniprot.org/citations/25966234 | http://purl.uniprot.org/core/volume | "14"xsd:string |
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