| http://purl.uniprot.org/citations/25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25969445 | http://www.w3.org/2000/01/rdf-schema#comment | "During the early steps of ribosome biogenesis in mammals, the two ribosomal subunits 40S and 60S are produced via splitting of the large 90S pre-ribosomal particle (90S) into pre-40S and pre-60S pre-ribosomal particles (pre-40S and pre-60S). We previously proposed that replacement of fibrillarin by Nop52 (RRP1/NNP-1) for the binding to p32 (C1QBP) is a key event that drives this splitting process. However, how the replacement by RRP1 is coupled with the endo-and/or exo-ribonucleolytic cleavage of pre-rRNA remains unknown. In this study, we demonstrate that RRP1 deficiency suppressed site 2 cleavage on ITS1 of 47S/45S, 41S and 36S pre-rRNAs in human cells. RRP1 was also present in 90S and was localized in the dense fibrillar component of the nucleolus dependently on active RNA polymerase I transcription. In addition, double knockdown of XRN2 and RRP1 revealed that RRP1 accelerated the site 2 cleavage of 47S, 45S and 41S pre-rRNAs. These data suggest that RRP1 is involved not only in competitive binding with fibrillarin to C1QBP on 90S but also in site 2 cleavage in ITS1 of pre-rRNAs at early stages of human ribosome biogenesis; thus, it is likely that RRP1 integrates the cleavage of site 2 with the physical split of 90S into pre-40S and pre-60S."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkv470"xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Ishikawa H."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Isobe T."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Yoshikawa H."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Simpson R.J."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Miura Y."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Izumikawa K."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/author | "Hayano T."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/pages | "5524-5536"xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/title | "Human nucleolar protein Nop52 (RRP1/NNP-1) is involved in site 2 cleavage in internal transcribed spacer 1 of pre-rRNAs at early stages of ribosome biogenesis."xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/25969445 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/25969445 |
| http://purl.uniprot.org/citations/25969445 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/25969445 |
| http://purl.uniprot.org/uniprot/#_Q14137-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |
| http://purl.uniprot.org/uniprot/#_Q15061-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |
| http://purl.uniprot.org/uniprot/#_B4DZM3-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |
| http://purl.uniprot.org/uniprot/#_O15213-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |
| http://purl.uniprot.org/uniprot/#_P62753-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |
| http://purl.uniprot.org/uniprot/#_Q13601-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |
| http://purl.uniprot.org/uniprot/#_Q14690-mappedCitation-25969445 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/25969445 |