| http://purl.uniprot.org/citations/25971596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/25971596 | http://www.w3.org/2000/01/rdf-schema#comment | "Resistance to HER2-targeted therapies remains a major obstacle in the treatment of HER2-overexpressing breast cancer. CD44, a putative breast cancer stem cell (CSC) marker, is overexpressed in trastuzumab-resistant breast cancer cells. While CSC-related genes may play a role in the development of trastuzumab resistance, conflicting results have been published about CSC response to trastuzumab. We hypothesized that CD44 contributes to trastuzumab resistance independently of its role as a CSC marker. We used trastuzumab-sensitive breast cancer cell lines and their trastuzumab-resistant isogenic counterparts to evaluate the role of CD44 in response to trastuzumab. miRNA and mRNA expression were analyzed using microarray chips. A gene set enrichment analysis was created and matched with response to trastuzumab in cells and patient samples. The proportions of CSC in trastuzumab-resistant cells were similar to or lower than in the trastuzumab-sensitive cells. However, CD44 expression levels were significantly higher in both trastuzumab-resistant cell lines and its knockdown led to an increased response to trastuzumab. The invasiveness and anchorage-independent growth of trastuzumab-resistant cells were higher and blocked by downregulation of CD44. Results also showed that CD44-related resistance to trastuzumab is regulated by miRNAs. We identified a CD44-related gene expression profile that correlated with response to trastuzumab in cell lines and breast cancer patients. CD44 mediates trastuzumab resistance in HER2-positive breast cancer cells independently of its role as a CSC marker and that this role of CD44 is partly regulated by miRNA."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10549-015-3414-3"xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/author | "Jin Q."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/author | "Esteva F.J."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/author | "Bartholomeusz C."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/author | "Boulbes D.R."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/author | "Chauhan G.B."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/date | "2015"xsd:gYear |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/name | "Breast Cancer Res Treat"xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/pages | "501-513"xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/title | "CD44 expression contributes to trastuzumab resistance in HER2-positive breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/25971596 | http://purl.uniprot.org/core/volume | "151"xsd:string |
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